Compare airlines and travel sites in one search No booking fees from us
FlightConnect
Search flights
  1. Home
  2. Flights
  3. Flights from Knoxville
  4. Knoxville to Des Moines
Connecting route · United States → United States

Flights from Knoxville to Des Moines

There are no direct flights from Knoxville to Des Moines. The fastest way is one stop via Atlanta or Chicago, about 3h 24m door to door (66 connections a week on current schedules).

No direct flights · 5 connection options From 3h 24m
TYSDSMORD

Knoxville to Des Moines at a glance

Fastest journey3h 24mVia Atlanta, on current schedules
Nonstop flightsNoneConnect via Atlanta or Chicago

Best ways to fly from Knoxville to Des Moines

Ranked by how easy the connection is: one airline or alliance first (bags and connection protected), then the quickest self-transfer options.

1
TYS Atlanta (ATL) DSM
Leg 1: Delta Air Lines, American Airlines · Leg 2: Delta Air Lines
Thu12:30 TYS13:08 ATL0h 52m connection14:00 ATL14:54 DSMDelta Air Lines
35 connections a week One airline, one ticket Fastest 3h 24m
Search
2
TYS Chicago (ORD) DSM
Leg 1: United Airlines, Envoy Air, GoJet Airlines · Leg 2: American Airlines, United Airlines, SkyWest
Thu18:30 TYS19:00 ORD1h 00m connection20:00 ORD21:06 DSMUnited Airlines
28 connections a week One airline, one ticket Fastest 3h 36m
Search
3
TYS Charlotte (CLT) DSM
Leg 1: American Airlines, Piedmont Airlines (1948-1989) · Leg 2: American Airlines
Sun16:15 TYS16:55 CLT5h 35m connection22:30 CLT23:31 DSMPiedmont Airlines (1948-1989) + American Airlines
3 connections a week One airline, one ticket Fastest 8h 16m
Search
4
TYS Fort Walton Beach (VPS) DSM
Leg 1: Allegiant Air · Leg 2: Allegiant Air
One airline, one ticket ~5h 02m
Search
5
TYS Nashville (BNA) DSM
Leg 1: Southwest Airlines · Leg 2: Allegiant Air
Self-transfer likely ~4h 52m
Search

Connections are computed from flights actually flown over the last 8 weeks, with at least 45 minutes to change on one airline and 2 hours on separate tickets. Times are local. The search shows live itineraries and exact times.

Good to know

Distance
1,047 km650 miles
Journey time
3h 24mon current schedules
Time difference
-1hDes Moines vs Knoxville
Currency in Des Moines
USD
Airports
TYS → DSM

Flights from Knoxville to Des Moines: questions answered

Are there direct flights from Knoxville to Des Moines?
No. There is no nonstop service, so you will connect, most easily in Atlanta, Chicago and Charlotte. Some connections are on one airline or alliance, so your bags and connection are protected on a single ticket.
How long is the flight from Knoxville to Des Moines?
With one connection the journey usually takes around 3h 24m, depending on the layover. The straight-line distance is 1,047 km.
Where do you change planes between Knoxville and Des Moines?
The best connecting points are Atlanta (ATL), Chicago (ORD), Charlotte (CLT) and Fort Walton Beach (VPS). Delta Air Lines flies both legs via Atlanta, so you can book it as one ticket.
Which airports serve Knoxville and Des Moines?
Knoxville: McGhee Tyson Airport (TYS). Des Moines: Des Moines International Airport (DSM).
What is the time difference between Knoxville and Des Moines?
Des Moines is 1 hour behind Knoxville.

More flights from Knoxville

Stunning view of Denver's cityscape with skyscrapers under a colorful sunset sky.NonstopDenverNonstopOne-way fromUS$216The reflective Cloud Gate sculpture in Chicago surrounded by iconic skyscrapers.NonstopChicagoNonstopSee the best way to goA captivating view of Atlanta's skyline with illuminated buildings and highways at night.NonstopAtlantaNonstopSee the best way to goCaptivating view of downtown Orlando skyline framed by trees at Lake Eola.NonstopOrlandoNonstopSee the best way to goVibrant long exposure of Downtown Los Angeles skyscrapers at night, showcasing the city skyline.1+ stopLos AngelesWith a connectionSee the best way to goExplore the dense urban landscape of Kansas City, featuring historic brick architecture and modern apartment buildings on a cloudy day.1+ stopKansas CityWith a connectionSee the best way to go