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Flights from Des Moines to Knoxville
There are no direct flights from Des Moines to Knoxville. The fastest way is one stop via Atlanta or Chicago, about 3h 43m door to door (65 connections a week on current schedules).
No direct flights · 5 connection options From 3h 43m
Des Moines to Knoxville at a glance
Fastest journey3h 43mVia Atlanta, on current schedules
Nonstop flightsNoneConnect via Atlanta or Chicago
Best ways to fly from Des Moines to Knoxville
Ranked by how easy the connection is: one airline or alliance first (bags and connection protected), then the quickest self-transfer options.
1Search
DSM Atlanta (ATL) TYS
Leg 1: Delta Air Lines · Leg 2: Delta Air Lines, American Airlines
Mon19:00 DSM21:49 ATL1h 11m connection23:00 ATL23:43 TYSDelta Air Lines
2Search
DSM Chicago (ORD) TYS
Leg 1: American Airlines, United Airlines, SkyWest · Leg 2: United Airlines, Envoy Air, GoJet Airlines
Tue11:30 DSM12:51 ORD1h 24m connection14:15 ORD16:40 TYSUnited Airlines
3Search
DSM Nashville (BNA) TYS
Leg 1: Allegiant Air · Leg 2: Southwest Airlines
Mon06:30 DSM07:51 BNA2h 39m connection10:30 BNA12:04 TYSAllegiant Air + Southwest Airlines
4Search
DSM Charlotte (CLT) TYS
Leg 1: American Airlines · Leg 2: American Airlines, Piedmont Airlines (1948-1989), SkyWest
Mon08:00 DSM11:00 CLT3h 15m connection14:15 CLT14:55 TYSAmerican Airlines + Piedmont Airlines (1948-1989)
Connections are computed from flights actually flown over the last 8 weeks, with at least 45 minutes to change on one airline and 2 hours on separate tickets. Times are local. The search shows live itineraries and exact times.
Good to know
- Distance
- 1,047 km650 miles
- Journey time
- 3h 43mon current schedules
- Time difference
- +1hKnoxville vs Des Moines
- Currency in Knoxville
- USD
- Airports
- DSM → TYS
Flights from Des Moines to Knoxville: questions answered
Are there direct flights from Des Moines to Knoxville?
No. There is no nonstop service, so you will connect, most easily in Atlanta, Chicago and Nashville. Some connections are on one airline or alliance, so your bags and connection are protected on a single ticket.
How long is the flight from Des Moines to Knoxville?
With one connection the journey usually takes around 3h 43m, depending on the layover. The straight-line distance is 1,047 km.
Where do you change planes between Des Moines and Knoxville?
The best connecting points are Atlanta (ATL), Chicago (ORD), Nashville (BNA) and Charlotte (CLT). Delta Air Lines flies both legs via Atlanta, so you can book it as one ticket.
Which airports serve Des Moines and Knoxville?
Des Moines: Des Moines International Airport (DSM). Knoxville: McGhee Tyson Airport (TYS).
What is the time difference between Des Moines and Knoxville?
Knoxville is 1 hour ahead of Des Moines.
