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Flights from St Louis to Des Moines
There are no direct flights from St Louis to Des Moines. The fastest way is one stop via Chicago or Nashville, about 3h 21m door to door (57 connections a week on current schedules).
No direct flights · 2 connection options From 3h 21m
St Louis to Des Moines at a glance
Fastest journey3h 21mVia Chicago, on current schedules
Nonstop flightsNoneConnect via Chicago or Nashville
Best ways to fly from St Louis to Des Moines
Ranked by how easy the connection is: one airline or alliance first (bags and connection protected), then the quickest self-transfer options.
1Search
STL Chicago (ORD) DSM
Leg 1: American Airlines, United Airlines, GoJet Airlines · Leg 2: American Airlines, United Airlines, SkyWest
Mon17:45 STL18:58 ORD1h 02m connection20:00 ORD21:06 DSMUnited Airlines
Connections are computed from flights actually flown over the last 8 weeks, with at least 45 minutes to change on one airline and 2 hours on separate tickets. Times are local. The search shows live itineraries and exact times.
Good to know
- Distance
- 439 km273 miles
- Journey time
- 3h 21mon current schedules
- Time difference
- NoneDes Moines vs St Louis
- Currency in Des Moines
- USD
- Airports
- STL → DSM
Flights from St Louis to Des Moines: questions answered
Are there direct flights from St Louis to Des Moines?
No. There is no nonstop service, so you will connect, most easily in Chicago and Nashville. Some connections are on one airline or alliance, so your bags and connection are protected on a single ticket.
How long is the flight from St Louis to Des Moines?
With one connection the journey usually takes around 3h 21m, depending on the layover. The straight-line distance is 439 km.
Where do you change planes between St Louis and Des Moines?
The best connecting points are Chicago (ORD) and Nashville (BNA). American Airlines flies both legs via Chicago, so you can book it as one ticket.
Which airports serve St Louis and Des Moines?
St Louis: St. Louis Lambert International Airport (STL). Des Moines: Des Moines International Airport (DSM).





