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Flights from Myrtle Beach to Knoxville
There are no direct flights from Myrtle Beach to Knoxville. The fastest way is one stop via Atlanta or Baltimore, about 2h 43m door to door (53 connections a week on current schedules).
No direct flights · 5 connection options From 2h 43m
Myrtle Beach to Knoxville at a glance
Fastest journey2h 43mVia Atlanta, on current schedules
Nonstop flightsNoneConnect via Atlanta or Baltimore
Best ways to fly from Myrtle Beach to Knoxville
Ranked by how easy the connection is: one airline or alliance first (bags and connection protected), then the quickest self-transfer options.
1Search
MYR Atlanta (ATL) TYS
Leg 1: Delta Air Lines · Leg 2: Delta Air Lines, American Airlines
Wed14:15 MYR15:12 ATL1h 03m connection16:15 ATL16:58 TYSDelta Air Lines
2Search
MYR Baltimore (BWI) TYS
Leg 1: Southwest Airlines · Leg 2: Southwest Airlines
Sun19:00 MYR20:04 BWI0h 56m connection21:00 BWI22:19 TYSSouthwest Airlines
3Search
MYR Nashville (BNA) TYS
Leg 1: Southwest Airlines · Leg 2: Southwest Airlines
Mon14:45 MYR14:58 BNA2h 02m connection17:00 BNA18:34 TYSSouthwest Airlines
4Search
MYR Charlotte (CLT) TYS
Leg 1: American Airlines · Leg 2: American Airlines, Piedmont Airlines (1948-1989), SkyWest
Mon12:15 MYR12:51 CLT3h 54m connection16:45 CLT17:24 TYSAmerican Airlines + SkyWest
Connections are computed from flights actually flown over the last 8 weeks, with at least 45 minutes to change on one airline and 2 hours on separate tickets. Times are local. The search shows live itineraries and exact times.
Good to know
- Distance
- 524 km325 miles
- Journey time
- 2h 43mon current schedules
- Time difference
- NoneKnoxville vs Myrtle Beach
- Currency in Knoxville
- USD
- Airports
- MYR → TYS
Flights from Myrtle Beach to Knoxville: questions answered
Are there direct flights from Myrtle Beach to Knoxville?
No. There is no nonstop service, so you will connect, most easily in Atlanta, Baltimore and Nashville. Some connections are on one airline or alliance, so your bags and connection are protected on a single ticket.
How long is the flight from Myrtle Beach to Knoxville?
With one connection the journey usually takes around 2h 43m, depending on the layover. The straight-line distance is 524 km.
Where do you change planes between Myrtle Beach and Knoxville?
The best connecting points are Atlanta (ATL), Baltimore (BWI), Nashville (BNA) and Charlotte (CLT). Delta Air Lines flies both legs via Atlanta, so you can book it as one ticket.
Which airports serve Myrtle Beach and Knoxville?
Myrtle Beach: Myrtle Beach International Airport (MYR). Knoxville: McGhee Tyson Airport (TYS).





