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Flights from Louisville to Des Moines
There are no direct flights from Louisville to Des Moines. The fastest way is one stop via Chicago or Nashville, about 4h 12m door to door (12 connections a week on current schedules).
No direct flights · 2 connection options From 4h 12m
Louisville to Des Moines at a glance
Fastest journey4h 12mVia Chicago, on current schedules
Nonstop flightsNoneConnect via Chicago or Nashville
Best ways to fly from Louisville to Des Moines
Ranked by how easy the connection is: one airline or alliance first (bags and connection protected), then the quickest self-transfer options.
1Search
SDF Chicago (ORD) DSM
Leg 1: Republic Airlines, SkyWest, Envoy Air · Leg 2: American Airlines, United Airlines, SkyWest
Sat05:30 SDF05:36 ORD2h 09m connection07:45 ORD08:42 DSMRepublic Airlines + SkyWest
Connections are computed from flights actually flown over the last 8 weeks, with at least 45 minutes to change on one airline and 2 hours on separate tickets. Times are local. The search shows live itineraries and exact times.
Good to know
- Distance
- 766 km476 miles
- Journey time
- 4h 12mon current schedules
- Time difference
- -1hDes Moines vs Louisville
- Currency in Des Moines
- USD
- Airports
- SDF → DSM
Flights from Louisville to Des Moines: questions answered
Are there direct flights from Louisville to Des Moines?
No. There is no nonstop service, so you will connect, most easily in Chicago and Nashville. Some connections are on one airline or alliance, so your bags and connection are protected on a single ticket.
How long is the flight from Louisville to Des Moines?
With one connection the journey usually takes around 4h 12m, depending on the layover. The straight-line distance is 766 km.
Where do you change planes between Louisville and Des Moines?
The best connecting points are Chicago (ORD) and Nashville (BNA). Republic Airlines flies both legs via Chicago, so you can book it as one ticket.
Which airports serve Louisville and Des Moines?
Louisville: Louisville Muhammad Ali International Airport (SDF). Des Moines: Des Moines International Airport (DSM).
What is the time difference between Louisville and Des Moines?
Des Moines is 1 hour behind Louisville.





