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Flights from Knoxville to Panama City
There are no direct flights from Knoxville to Panama City. The fastest way is one stop via Atlanta or Nashville, about 2h 22m door to door (46 connections a week on current schedules).
No direct flights · 3 connection options From 2h 22m
Knoxville to Panama City at a glance
Fastest journey2h 22mVia Atlanta, on current schedules
Nonstop flightsNoneConnect via Atlanta or Nashville
Best ways to fly from Knoxville to Panama City
Ranked by how easy the connection is: one airline or alliance first (bags and connection protected), then the quickest self-transfer options.
1Search
TYS Atlanta (ATL) ECP
Leg 1: Delta Air Lines, American Airlines · Leg 2: Delta Air Lines
Sun18:30 TYS19:08 ATL0h 52m connection20:00 ATL19:52 ECPDelta Air Lines
2Search
TYS Nashville (BNA) ECP
Leg 1: Southwest Airlines · Leg 2: Southwest Airlines
Sat07:00 TYS06:35 BNA1h 10m connection07:45 BNA08:47 ECPSouthwest Airlines
3Search
TYS Charlotte (CLT) ECP
Leg 1: American Airlines, Piedmont Airlines (1948-1989) · Leg 2: American Airlines
Connections are computed from flights actually flown over the last 8 weeks, with at least 45 minutes to change on one airline and 2 hours on separate tickets. Times are local. The search shows live itineraries and exact times.
Good to know
- Distance
- 665 km413 miles
- Journey time
- 2h 22mon current schedules
- Time difference
- -1hPanama City vs Knoxville
- Currency in Panama City
- USD
- Airports
- TYS → ECP
Flights from Knoxville to Panama City: questions answered
Are there direct flights from Knoxville to Panama City?
No. There is no nonstop service, so you will connect, most easily in Atlanta, Nashville and Charlotte. Some connections are on one airline or alliance, so your bags and connection are protected on a single ticket.
How long is the flight from Knoxville to Panama City?
With one connection the journey usually takes around 2h 22m, depending on the layover. The straight-line distance is 665 km.
Where do you change planes between Knoxville and Panama City?
The best connecting points are Atlanta (ATL), Nashville (BNA) and Charlotte (CLT). Delta Air Lines flies both legs via Atlanta, so you can book it as one ticket.
Which airports serve Knoxville and Panama City?
Knoxville: McGhee Tyson Airport (TYS). Panama City: Northwest Florida Beaches International Airport (ECP).
What is the time difference between Knoxville and Panama City?
Panama City is 1 hour behind Knoxville.





