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Flights from Knoxville to Buffalo
There are no direct flights from Knoxville to Buffalo. The fastest way is one stop via Baltimore or Atlanta, about 3h 11m door to door (82 connections a week on current schedules).
No direct flights · 6 connection options From 3h 11m
Knoxville to Buffalo at a glance
Fastest journey3h 11mVia Baltimore, on current schedules
Nonstop flightsNoneConnect via Baltimore or Atlanta
Best ways to fly from Knoxville to Buffalo
Ranked by how easy the connection is: one airline or alliance first (bags and connection protected), then the quickest self-transfer options.
1Search
TYS Baltimore (BWI) BUF
Leg 1: Southwest Airlines · Leg 2: Southwest Airlines
Thu08:30 TYS09:48 BWI0h 57m connection10:45 BWI11:41 BUFSouthwest Airlines
2Search
TYS Atlanta (ATL) BUF
Leg 1: Delta Air Lines, American Airlines · Leg 2: Delta Air Lines, Frontier Airlines
Sun20:15 TYS20:53 ATL0h 52m connection21:45 ATL23:33 BUFDelta Air Lines
3Search
TYS Charlotte (CLT) BUF
Leg 1: American Airlines, Piedmont Airlines (1948-1989) · Leg 2: American Airlines
Mon11:00 TYS11:40 CLT2h 05m connection13:45 CLT15:07 BUFPiedmont Airlines (1948-1989) + American Airlines
4Search
TYS Chicago (ORD) BUF
Leg 1: United Airlines, Envoy Air, GoJet Airlines · Leg 2: American Airlines, United Airlines, Envoy Air
Sun18:15 TYS18:45 ORD1h 45m connection20:30 ORD22:47 BUFUnited Airlines
5Search
TYS New York (EWR) BUF
Leg 1: Allegiant Air, GoJet Airlines · Leg 2: United Airlines, GoJet Airlines
Mon09:15 TYS10:49 EWR2h 56m connection13:45 EWR14:51 BUFAllegiant Air + GoJet Airlines
6Search
TYS Nashville (BNA) BUF
Leg 1: Southwest Airlines · Leg 2: Southwest Airlines
Sat07:00 TYS06:35 BNA3h 55m connection10:30 BNA12:58 BUFSouthwest Airlines
Connections are computed from flights actually flown over the last 8 weeks, with at least 45 minutes to change on one airline and 2 hours on separate tickets. Times are local. The search shows live itineraries and exact times.
Good to know
- Distance
- 883 km548 miles
- Journey time
- 3h 11mon current schedules
- Time difference
- NoneBuffalo vs Knoxville
- Currency in Buffalo
- USD
- Airports
- TYS → BUF
Flights from Knoxville to Buffalo: questions answered
Are there direct flights from Knoxville to Buffalo?
No. There is no nonstop service, so you will connect, most easily in Baltimore, Atlanta and Charlotte. Some connections are on one airline or alliance, so your bags and connection are protected on a single ticket.
How long is the flight from Knoxville to Buffalo?
With one connection the journey usually takes around 3h 11m, depending on the layover. The straight-line distance is 883 km.
Where do you change planes between Knoxville and Buffalo?
The best connecting points are Baltimore (BWI), Atlanta (ATL), Charlotte (CLT) and Chicago (ORD). Southwest Airlines flies both legs via Baltimore, so you can book it as one ticket.
Which airports serve Knoxville and Buffalo?
Knoxville: McGhee Tyson Airport (TYS). Buffalo: Buffalo Niagara International Airport (BUF).





