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Flights from Key West to Des Moines
There are no direct flights from Key West to Des Moines. The fastest way is one stop via Atlanta or Charlotte, about 4h 24m door to door (21 connections a week on current schedules).
No direct flights · 6 connection options From 4h 24m
Key West to Des Moines at a glance
Fastest journey4h 24mVia Atlanta, on current schedules
Nonstop flightsNoneConnect via Atlanta or Charlotte
Best ways to fly from Key West to Des Moines
Ranked by how easy the connection is: one airline or alliance first (bags and connection protected), then the quickest self-transfer options.
1Search
EYW Atlanta (ATL) DSM
Leg 1: Delta Air Lines · Leg 2: Delta Air Lines
Wed11:45 EYW13:30 ATL0h 45m connection14:15 ATL15:09 DSMDelta Air Lines
2Search
EYW Charlotte (CLT) DSM
Leg 1: American Airlines · Leg 2: American Airlines
Thu14:15 EYW16:15 CLT1h 15m connection17:30 CLT18:31 DSMAmerican Airlines
3Search
EYW Orlando (MCO) DSM
Leg 1: Breeze Airways · Leg 2: Frontier Airlines, Allegiant Air, Breeze Airways
4Search
EYW Chicago (ORD) DSM
Leg 1: United Airlines · Leg 2: American Airlines, United Airlines, SkyWest
Connections are computed from flights actually flown over the last 8 weeks, with at least 45 minutes to change on one airline and 2 hours on separate tickets. Times are local. The search shows live itineraries and exact times.
Good to know
- Distance
- 2,187 km1,358 miles
- Journey time
- 4h 24mon current schedules
- Time difference
- -1hDes Moines vs Key West
- Currency in Des Moines
- USD
- Airports
- EYW → DSM
Flights from Key West to Des Moines: questions answered
Are there direct flights from Key West to Des Moines?
No. There is no nonstop service, so you will connect, most easily in Atlanta, Charlotte and Orlando. Some connections are on one airline or alliance, so your bags and connection are protected on a single ticket.
How long is the flight from Key West to Des Moines?
With one connection the journey usually takes around 4h 24m, depending on the layover. The straight-line distance is 2,187 km.
Where do you change planes between Key West and Des Moines?
The best connecting points are Atlanta (ATL), Charlotte (CLT), Orlando (MCO) and Chicago (ORD). Delta Air Lines flies both legs via Atlanta, so you can book it as one ticket.
Which airports serve Key West and Des Moines?
Key West: Key West International Airport (EYW). Des Moines: Des Moines International Airport (DSM).
What is the time difference between Key West and Des Moines?
Des Moines is 1 hour behind Key West.





