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Flights from Des Moines to Key West
There are no direct flights from Des Moines to Key West. The fastest way is one stop via Atlanta or Tampa, about 4h 40m door to door (18 connections a week on current schedules).
No direct flights · 6 connection options From 4h 40m
Des Moines to Key West at a glance
Fastest journey4h 40mVia Atlanta, on current schedules
Nonstop flightsNoneConnect via Atlanta or Tampa
Best ways to fly from Des Moines to Key West
Ranked by how easy the connection is: one airline or alliance first (bags and connection protected), then the quickest self-transfer options.
1Search
DSM Atlanta (ATL) EYW
Leg 1: Delta Air Lines · Leg 2: Delta Air Lines
Wed11:30 DSM14:19 ATL1h 11m connection15:30 ATL17:10 EYWDelta Air Lines
2Search
DSM Tampa (PIE) EYW
Leg 1: Allegiant Air · Leg 2: Allegiant Air
Fri19:45 DSM23:14 PIE8h 31m connection07:45 PIE08:43 EYWAllegiant Air
3Search
DSM Orlando (MCO) EYW
Leg 1: Frontier Airlines, Allegiant Air, Breeze Airways · Leg 2: Breeze Airways
4Search
DSM Chicago (ORD) EYW
Leg 1: American Airlines, United Airlines, SkyWest · Leg 2: United Airlines
Connections are computed from flights actually flown over the last 8 weeks, with at least 45 minutes to change on one airline and 2 hours on separate tickets. Times are local. The search shows live itineraries and exact times.
Good to know
- Distance
- 2,187 km1,358 miles
- Journey time
- 4h 40mon current schedules
- Time difference
- +1hKey West vs Des Moines
- Currency in Key West
- USD
- Airports
- DSM → EYW
Flights from Des Moines to Key West: questions answered
Are there direct flights from Des Moines to Key West?
No. There is no nonstop service, so you will connect, most easily in Atlanta, Tampa and Orlando. Some connections are on one airline or alliance, so your bags and connection are protected on a single ticket.
How long is the flight from Des Moines to Key West?
With one connection the journey usually takes around 4h 40m, depending on the layover. The straight-line distance is 2,187 km.
Where do you change planes between Des Moines and Key West?
The best connecting points are Atlanta (ATL), Tampa (PIE), Orlando (MCO) and Chicago (ORD). Delta Air Lines flies both legs via Atlanta, so you can book it as one ticket.
Which airports serve Des Moines and Key West?
Des Moines: Des Moines International Airport (DSM). Key West: Key West International Airport (EYW).
What is the time difference between Des Moines and Key West?
Key West is 1 hour ahead of Des Moines.





