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Flights from Greenville to Des Moines
There are no direct flights from Greenville to Des Moines. The fastest way is one stop via Charlotte or Atlanta, about 3h 31m door to door (89 connections a week on current schedules).
No direct flights · 6 connection options From 3h 31m
Greenville to Des Moines at a glance
Fastest journey3h 31mVia Charlotte, on current schedules
Nonstop flightsNoneConnect via Charlotte or Atlanta
Best ways to fly from Greenville to Des Moines
Ranked by how easy the connection is: one airline or alliance first (bags and connection protected), then the quickest self-transfer options.
1Search
GSP Charlotte (CLT) DSM
Leg 1: American Airlines, Piedmont Airlines (1948-1989) · Leg 2: American Airlines
Sun21:00 GSP21:29 CLT1h 01m connection22:30 CLT23:31 DSMAmerican Airlines
2Search
GSP Atlanta (ATL) DSM
Leg 1: Delta Air Lines · Leg 2: Delta Air Lines
Mon12:15 GSP12:53 ATL1h 07m connection14:00 ATL14:54 DSMDelta Air Lines
3Search
GSP Chicago (ORD) DSM
Leg 1: United Airlines, GoJet Airlines, Envoy Air · Leg 2: American Airlines, United Airlines, SkyWest
Tue07:00 GSP07:48 ORD1h 27m connection09:15 ORD10:21 DSMUnited Airlines
4Search
GSP Dallas (DFW) DSM
Leg 1: American Airlines · Leg 2: American Airlines
Mon18:00 GSP19:11 DFW2h 19m connection21:30 DFW23:07 DSMAmerican Airlines
Connections are computed from flights actually flown over the last 8 weeks, with at least 45 minutes to change on one airline and 2 hours on separate tickets. Times are local. The search shows live itineraries and exact times.
Good to know
- Distance
- 1,232 km765 miles
- Journey time
- 3h 31mon current schedules
- Time difference
- -1hDes Moines vs Greenville
- Currency in Des Moines
- USD
- Airports
- GSP → DSM
Flights from Greenville to Des Moines: questions answered
Are there direct flights from Greenville to Des Moines?
No. There is no nonstop service, so you will connect, most easily in Charlotte, Atlanta and Chicago. Some connections are on one airline or alliance, so your bags and connection are protected on a single ticket.
How long is the flight from Greenville to Des Moines?
With one connection the journey usually takes around 3h 31m, depending on the layover. The straight-line distance is 1,232 km.
Where do you change planes between Greenville and Des Moines?
The best connecting points are Charlotte (CLT), Atlanta (ATL), Chicago (ORD) and Dallas (DFW). American Airlines flies both legs via Charlotte, so you can book it as one ticket.
Which airports serve Greenville and Des Moines?
Greenville: Greenville-Spartanburg International Airport (GSP). Des Moines: Des Moines International Airport (DSM).
What is the time difference between Greenville and Des Moines?
Des Moines is 1 hour behind Greenville.





