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Flights from Des Moines to Greenville
There are no direct flights from Des Moines to Greenville. The fastest way is one stop via Atlanta or Charlotte, about 3h 27m door to door (71 connections a week on current schedules).
No direct flights · 5 connection options From 3h 27m
Des Moines to Greenville at a glance
Fastest journey3h 27mVia Atlanta, on current schedules
Nonstop flightsNoneConnect via Atlanta or Charlotte
Best ways to fly from Des Moines to Greenville
Ranked by how easy the connection is: one airline or alliance first (bags and connection protected), then the quickest self-transfer options.
1Search
DSM Atlanta (ATL) GSP
Leg 1: Delta Air Lines · Leg 2: Delta Air Lines
Wed11:30 DSM14:19 ATL0h 56m connection15:15 ATL15:57 GSPDelta Air Lines
2Search
DSM Charlotte (CLT) GSP
Leg 1: American Airlines · Leg 2: American Airlines
Wed13:30 DSM16:30 CLT1h 45m connection18:15 CLT18:39 GSPAmerican Airlines
3Search
DSM Chicago (ORD) GSP
Leg 1: American Airlines, United Airlines, SkyWest · Leg 2: United Airlines, GoJet Airlines, Envoy Air
Sun07:30 DSM08:45 ORD2h 00m connection10:45 ORD13:12 GSPRepublic Airlines + GoJet Airlines
4Search
DSM Dallas (DFW) GSP
Leg 1: American Airlines · Leg 2: American Airlines, Envoy Air
Mon16:15 DSM18:02 DFW0h 58m connection19:00 DFW22:04 GSPAmerican Airlines
5Search
DSM Nashville (BNA) GSP
Leg 1: Allegiant Air · Leg 2: Southwest Airlines
Mon06:30 DSM07:51 BNA2h 39m connection10:30 BNA12:19 GSPAllegiant Air + Southwest Airlines
Connections are computed from flights actually flown over the last 8 weeks, with at least 45 minutes to change on one airline and 2 hours on separate tickets. Times are local. The search shows live itineraries and exact times.
Good to know
- Distance
- 1,232 km765 miles
- Journey time
- 3h 27mon current schedules
- Time difference
- +1hGreenville vs Des Moines
- Currency in Greenville
- USD
- Airports
- DSM → GSP
Flights from Des Moines to Greenville: questions answered
Are there direct flights from Des Moines to Greenville?
No. There is no nonstop service, so you will connect, most easily in Atlanta, Charlotte and Chicago. Some connections are on one airline or alliance, so your bags and connection are protected on a single ticket.
How long is the flight from Des Moines to Greenville?
With one connection the journey usually takes around 3h 27m, depending on the layover. The straight-line distance is 1,232 km.
Where do you change planes between Des Moines and Greenville?
The best connecting points are Atlanta (ATL), Charlotte (CLT), Chicago (ORD) and Dallas (DFW). Delta Air Lines flies both legs via Atlanta, so you can book it as one ticket.
Which airports serve Des Moines and Greenville?
Des Moines: Des Moines International Airport (DSM). Greenville: Greenville-Spartanburg International Airport (GSP).
What is the time difference between Des Moines and Greenville?
Greenville is 1 hour ahead of Des Moines.
