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Flights from Syracuse to Knoxville
There are no direct flights from Syracuse to Knoxville. The fastest way is one stop via Atlanta or Chicago, about 4h 13m door to door (51 connections a week on current schedules).
No direct flights · 6 connection options From 4h 13m
Syracuse to Knoxville at a glance
Fastest journey4h 13mVia Atlanta, on current schedules
Nonstop flightsNoneConnect via Atlanta or Chicago
Best ways to fly from Syracuse to Knoxville
Ranked by how easy the connection is: one airline or alliance first (bags and connection protected), then the quickest self-transfer options.
1Search
SYR Atlanta (ATL) TYS
Leg 1: Delta Air Lines · Leg 2: Delta Air Lines, American Airlines
Thu12:15 SYR14:19 ATL1h 26m connection15:45 ATL16:28 TYSDelta Air Lines
2Search
SYR Chicago (ORD) TYS
Leg 1: American Airlines, United Airlines, SkyWest · Leg 2: United Airlines, Envoy Air, GoJet Airlines
Mon18:15 SYR19:17 ORD0h 58m connection20:15 ORD22:40 TYSUnited Airlines
3Search
SYR Boston (BOS) TYS
Leg 1: JetBlue Airways, Delta Air Lines, Envoy Air · Leg 2: Allegiant Air
Sat09:15 SYR10:11 BOS2h 19m connection12:30 BOS14:44 TYSJetBlue Airways + Allegiant Air
4Search
SYR Charlotte (CLT) TYS
Leg 1: American Airlines · Leg 2: American Airlines, Piedmont Airlines (1948-1989), SkyWest
Mon08:00 SYR09:46 CLT4h 29m connection14:15 CLT14:55 TYSAmerican Airlines + Piedmont Airlines (1948-1989)
5Search
SYR Washington (IAD) TYS
Leg 1: Republic Airlines, CommutAir, GoJet Airlines · Leg 2: Allegiant Air, CommutAir, Mesa Airlines
Sun16:00 SYR17:11 IAD5h 04m connection22:15 IAD23:38 TYSCommutAir
Connections are computed from flights actually flown over the last 8 weeks, with at least 45 minutes to change on one airline and 2 hours on separate tickets. Times are local. The search shows live itineraries and exact times.
Good to know
- Distance
- 1,031 km640 miles
- Journey time
- 4h 13mon current schedules
- Time difference
- NoneKnoxville vs Syracuse
- Currency in Knoxville
- USD
- Airports
- SYR → TYS
Flights from Syracuse to Knoxville: questions answered
Are there direct flights from Syracuse to Knoxville?
No. There is no nonstop service, so you will connect, most easily in Atlanta, Chicago and Boston. Some connections are on one airline or alliance, so your bags and connection are protected on a single ticket.
How long is the flight from Syracuse to Knoxville?
With one connection the journey usually takes around 4h 13m, depending on the layover. The straight-line distance is 1,031 km.
Where do you change planes between Syracuse and Knoxville?
The best connecting points are Atlanta (ATL), Chicago (ORD), Boston (BOS) and Charlotte (CLT). Delta Air Lines flies both legs via Atlanta, so you can book it as one ticket.
Which airports serve Syracuse and Knoxville?
Syracuse: Syracuse Hancock International Airport (SYR). Knoxville: McGhee Tyson Airport (TYS).





