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Flights from St Louis to Key West
There are no direct flights from St Louis to Key West. The fastest way is one stop via Atlanta or Charlotte, about 4h 10m door to door (67 connections a week on current schedules).
No direct flights · 6 connection options From 4h 10m
St Louis to Key West at a glance
Fastest journey4h 10mVia Atlanta, on current schedules
Nonstop flightsNoneConnect via Atlanta or Charlotte
Best ways to fly from St Louis to Key West
Ranked by how easy the connection is: one airline or alliance first (bags and connection protected), then the quickest self-transfer options.
1Search
STL Atlanta (ATL) EYW
Leg 1: Delta Air Lines, Frontier Airlines, Southwest Airlines · Leg 2: Delta Air Lines
Tue14:30 STL16:50 ATL1h 10m connection18:00 ATL19:40 EYWDelta Air Lines
2Search
STL Charlotte (CLT) EYW
Leg 1: American Airlines, Southwest Airlines · Leg 2: American Airlines
Wed06:45 STL09:20 CLT1h 40m connection11:00 CLT12:58 EYWAmerican Airlines
3Search
STL Orlando (MCO) EYW
Leg 1: Frontier Airlines, Southwest Airlines · Leg 2: Breeze Airways
Sun21:45 STL00:49 MCO8h 11m connection09:00 MCO10:00 EYWSouthwest Airlines + Breeze Airways
5Search
STL Chicago (ORD) EYW
Leg 1: American Airlines, United Airlines, GoJet Airlines · Leg 2: United Airlines
6Search
STL Dallas (DFW) EYW
Leg 1: American Airlines, Frontier Airlines, Envoy Air · Leg 2: American Airlines
Connections are computed from flights actually flown over the last 8 weeks, with at least 45 minutes to change on one airline and 2 hours on separate tickets. Times are local. The search shows live itineraries and exact times.
Good to know
- Distance
- 1,754 km1,089 miles
- Journey time
- 4h 10mon current schedules
- Time difference
- +1hKey West vs St Louis
- Currency in Key West
- USD
- Airports
- STL → EYW
Flights from St Louis to Key West: questions answered
Are there direct flights from St Louis to Key West?
No. There is no nonstop service, so you will connect, most easily in Atlanta, Charlotte and Orlando. Some connections are on one airline or alliance, so your bags and connection are protected on a single ticket.
How long is the flight from St Louis to Key West?
With one connection the journey usually takes around 4h 10m, depending on the layover. The straight-line distance is 1,754 km.
Where do you change planes between St Louis and Key West?
The best connecting points are Atlanta (ATL), Charlotte (CLT), Orlando (MCO) and Miami (MIA). Delta Air Lines flies both legs via Atlanta, so you can book it as one ticket.
Which airports serve St Louis and Key West?
St Louis: St. Louis Lambert International Airport (STL). Key West: Key West International Airport (EYW).
What is the time difference between St Louis and Key West?
Key West is 1 hour ahead of St Louis.





